A Cryo-EM and AI-Driven Approach to Better Drug Design

Gandeeva’s mission is to identify key druggable transient protein interactions using advanced AI approaches, visualize them with atomic resolution cryo-EM, and design precise, first-in-class molecular glues that bind specifically at these protein interfaces. This strategy allows us to discover potent, effective drugs against previously inaccessible targets

The Gandeeva Platform

Gandeeva’s technology includes three proprietary platform modules working together to shorten the timeline for drug discovery. Our approach enables us to tackle a wide spectrum of therapeutic targets ranging from protein-protein complexes and nucleic acid-protein complexes to membrane proteins.

SPOTLIGHTTM

SPOTLIGHTTM illuminates a spectrum of therapeutic targets, from protein-protein complexes, nucleic acid-protein complexes, to membrane proteins.

HYPERFOCUSTM

HYPERFOCUSTM drives computational and empirical identification of druggable targets prioritized by SPOTLIGHTTM and validated by cryo-EM.

CRYO-CADDTM

CRYO-CADDTM powers Gandeeva’s drug discovery engine through a rapid and iterative cycle that generates structural insights.

See Gandeeva’s platform in action

At Gandeeva Therapeutics, we are revolutionizing the drug discovery paradigm by applying recent ground-breaking advances in computational predictions, machine learning and cryo-EM imaging to develop precision medicines for our most challenging diseases. By combining structural biology, imaging, and computational tools, Gandeeva scientists are working to influence how proteins interact by engineering therapeutic interventions at key protein interfaces.

Interdisciplinary insights to build better drugs

Our proprietary platform combines breakthrough technologies across chemistry, biology, imaging and machine learning. We visualize, measure and capture protein-protein and protein-drug interactions with unprecedented speed and resolution to precisely target disease-relevant proteins and influence their function.